Also advise patients to avoid close contact with infants and pregnant women during the first 12 hours after administration of gallium Ga 68 dotatate.īetamethasone: (Moderate) Repeated administration of high corticosteroid doses prior to gallium Ga 68 dotatate may result in false negative imaging. Advise patients to drink a sufficient amount of water to ensure adequate hydration prior to gallium Ga 68 dotatate administration, and instruct patients to drink and void frequently during the first hours after gallium Ga 68 dotatate administration to reduce radiation exposure. Furthermore, care should be taken to minimize radiation exposure to the patient through proper patient management before, during, and after the procedure. Care should be taken to assure minimal accidental exposure of radiation to occupational workers, including use of waterproof gloves and effective shielding. Gallium Ga 68 dotatate should only be used by physicians or radiopharmacists who are qualified by training and experience in the safe use and handling of radioactive materials, and whose experience and training have been approved by the appropriate governmental agency authorized to license the use of radionuclides. NOTE: Storage and disposal should be controlled in compliance with appropriate regulations of the governmental agency authorized to license the use of radiopharmaceuticals. Radiopharmaceuticals should only be used by nuclear physicians and/or radiopharmacists who are qualified by specific training and experienced in the safe use and handling of radioactive material, and whose experience and training have been approved by the appropriate governmental agency authorized to license the use of radiopharmaceuticals. To minimize radiation exposure to occupational workers and patients, observe appropriate precautions that are consistent with proper patient management. Before reconstitution and radiolabeling with gallium Ga 68, the contents of the kit are not radioactive. NOTE: The radionuclide is not part of the kit. Patients should drink and void frequently during the first hours after administration to reduce radiation exposure. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.NOTE: Instruct patients to drink a sufficient amount of water to ensure adequate hydration prior to the administration of gallium Ga 68 dotatate. Furthermore, the shelf life of more than 24 h and the scanning window of at least 3 h make 64Cu-DOTATATE favorable and easy to use in the clinical setting.Ħ4Cu-DOTATATE 68Ga-DOTATOC PET/CT neuroendocrine tumors somatostatin receptor imaging. Although patient-based sensitivity was the same for 64Cu-DOTATATE and 68Ga-DOTATOC in this cohort, significantly more lesions were detected by 64Cu-DOTATATE. Conclusion: 64Cu-DOTATATE has advantages over 68Ga-DOTATOC in the detection of lesions in NET patients. All patients with additional lesions also had concordant lesions found by both scans. On a patient-basis, additional true lesions were found by 64Cu-DOTATATE and 68Ga-DOTATOC in 13 and 3 patients, respectively. Accordingly, 83% of the additional true lesions found on only one of the scans were found by 64Cu-DOTATATE. False-positives were mainly lymph node lesions. 68Ga-DOTATOC showed 26 lesions not found on 64Cu-DOTATATE, of which 7 were found to be true-positive on follow-up. 64Cu-DOTATATE showed 42 lesions not found on 68Ga-DOTATOC, of which 33 were found to be true-positive on follow-up. Results: A total of 701 lesions were concordantly detected on both 64Cu-DOTATATE and 68Ga-DOTATOC PET/CT scans, whereas an additional 68 lesions were found by only one of the scans. Discordant lesions were verified during at least 30 mo of follow-up. Methods: Fifty-nine NET patients were scanned with both 64Cu-DOTATATE and 68Ga-DOTATOC PET/CT and compared on a head-to-head basis. To test this hypothesis, we compared on a head-to-head basis the diagnostic performance of 64Cu-DOTATATE with that of 68Ga-DOTATOC in NET patients. Because of the advantages of 64Cu over 68Ga, we hypothesized that the tracer has a higher sensitivity than 68Ga-based tracers. 64Cu-DOTATATE is a new PET tracer that has been shown to be far superior to the SPECT tracer 111In-diethylenetriaminepentaacetic acid-octreotide. PET-based tracers using 68Ga as the radioisotope have in most centers replaced SPECT-based tracers as the gold standard. Somatostatin receptor imaging is a valuable tool in the diagnosis, follow-up, and treatment planning of neuroendocrine tumor (NET).
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